| TITLE: | Lipoprotein(a) and oxygen free radicals in survivors of acute myocardial infarction: effects of captopril. | ||||||
|---|---|---|---|---|---|---|---|
| AUTHOR: | Sogaard P; Klausen IC; Rungby J; Faergeman O; Thygesen K | ||||||
| AUTHOR AFFILIATION: | Department of Cardiology, Aarhus University Hospital, Denmark. | ||||||
| SOURCE: | Cardiology 1996 Jan-Feb;87(1):18-22 | ||||||
| NLM CIT. ID: | 96192312 | ||||||
| ABSTRACT: | Long-term treatment of survivors of an acute myocardial infarction with angiotensin-converting enzyme inhibitors has a beneficial impact on their long-term outcome. We tested the hypothesis that captopril could reductively cleave the lipoprotein(a) molecule and in addition act as a scavenger of oxygen free radicals. In a double-blind trial, 20 patients were randomized to receive either captopril 50 mg daily or corresponding placebo. patients were followed for a period of 30 days. Blood samples were drawn prior to randomization and after 30 days of treatment. Plasma concentrations of lipoprotein(a) and malondialdehyde were evaluated. Captopril treatment produced a significant reduction in plasma content of lipoprotein(a) ( < 0.05) and at day 30 the plasma content of lipoprotein(a) was also significantly lower than that in the placebo group (p < 0.05). furthermore, on day 30 plasma concentrations of malondialdehyde, an indicator of oxidative damage, were significantly lower in the captopril group when compared to baseline values and corresponding placebo group values (p < 0.05). The observed effect of captopril treatment on lipoprotein(a) and malondialdehyde might be ascribed to the sulfhydryl group in the captopril molecule. | ||||||
| MAIN MESH SUBJECTS: |
Angiotensin-Converting Enzyme Inhibitors/*THERAPEUTIC USE Captopril/*THERAPEUTIC USE Lipoprotein(a)/BLOOD/*DRUG EFFECTS Malondialdehyde/*BLOOD Myocardial Infarction/BLOOD/*DRUG THERAPY | ||||||
| ADDITIONAL MESH SUBJECTS: |
Double-Blind Method Female Follow-Up Studies Free Radicals/BLOOD Human Male Middle Age Oxygen/BLOOD Support, Non-U.S. Gov't Survivors Treatment Outcome | ||||||
| PUBLICATION TYPES: |
CLINICAL TRIAL JOURNAL ARTICLE RANDOMIZED CONTROLLED TRIAL | ||||||
| LANGUAGE: | Eng | ||||||
| REGISTRY NUMBERS: |
0 (Angiotensin-Converting Enzyme Inhibitors) 0 (Free Radicals) 0 (Lipoprotein(a)) 542-78-9 (Malondialdehyde) 62571-86-2 (Captopril) 7782-44-7 (Oxygen) | ||||||