National Library of Medicine: IGM Full Record Screen

Citations 85 to 88 of 986 from MEDLINE 1994-97

TITLE: In vivo transfer of lipoprotein(a) into human atherosclerotic carotid arterial intima.
AUTHOR: Nielsen LB; Gronholdt ML; Schroeder TV; Stender S; Nordestgaard BG
AUTHOR AFFILIATION: Department of Clinical Biochemistry, Rigshospitalet, Herlev, Denmark.
SOURCE: Arterioscler Thromb Vasc Biol 1997 May;17(5):905-11
NLM CIT. ID: 97301553
ABSTRACT: The aim of this study was to compare the atherogenic potential of lipoprotein(a) [Lp(a)] and LDL by measuring the intimal clearance of these two plasma lipoproteins in the atherosclerotic intima of the human carotid artery in vivo. Autologous 131I-Lp(a) and 125I-LDL were mixed and reinjected intravenously 3 hours before elective surgical removal of the arterial intima in four patients. The intimal clearance of Lp(a) and LDL was 229+/-48 and 405+/-127 nL/cm2 per hour, respectively (paired t test; P=.12). The mass accumulation of Lp(a) (114+/-32 ng/cm2 per hour) was on average one 15th that of LDL (paired t test; P=.06), mainly reflecting a low plasma concentration of Lp(a) compared with LDL in the human subjects studied. In accordance with our previous observation in rabbits, there was a positive association between the intimal clearance of LDL and that of Lp(a) (r=.97, P=.03). Accordingly, high plasma levels of Lp(a) may share with LDL the potential for causing lipid accumulation in the arterial intima in humans.
MAIN MESH SUBJECTS: Atherosclerosis/*METABOLISM
Carotid Arteries/*METABOLISM/PATHOLOGY
Lipoprotein(a)/BLOOD/*METABOLISM
ADDITIONAL MESH SUBJECTS: Aged
Centrifugation, Density Gradient
Chromatography, Gel
Electrophoresis, Agar Gel
Female
Human
Iodine Radioisotopes
Lipoproteins, LDL/BLOOD/METABOLISM
Male
Middle Age
Support, Non-U.S. Gov't
PUBLICATION TYPES: JOURNAL ARTICLE
LANGUAGE: Eng
REGISTRY NUMBERS: 0 (Iodine Radioisotopes)
0 (Lipoprotein(a))
0 (Lipoproteins, LDL)