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Citations 64 to 64 of 986 from MEDLINE 1994-97

TITLE: Lipoprotein Lp(a) excess and coronary heart disease [see comments]
AUTHOR: Stein JH; Rosenson RS
AUTHOR AFFILIATION: Section of Cardiology, University of Wisconsin Medical School, Madison, USA.
SOURCE: Arch Intern Med 1997 Jun 9;157(11):1170-6
NLM CIT. ID: 97326406
COMMENT: Arch Intern Med 1997 Jun 9;157(11):1161-2
ABSTRACT: Lipoprotein Lp(a) excess has been identified as a powerful predictor of premature atherosclerotic vascular disease in several large, prospective studies. Lipoprotein Lp(a) levels modulate the risk of coronary heart disease in patients with hypercholesterolemia, and lipoprotein Lp(a) excess is commonly detected in men and women with premature coronary atherosclerosis. Lipoprotein Lp(a) contributes to atherothrombotic risk by multiple mechanisms that include impaired fibrinolysis, increased cholesterol deposition in the arterial wall, and enhanced oxidation of low density lipoprotein cholesterol. Although low density lipoprotein cholesterol reduction is the primary intervention in patients with lipoprotein Lp(a) excess, specific therapy to lower lipoprotein Lp(a) may be indicated for patients with premature coronary atherosclerosis, a strong family history of premature atherosclerosis, or refractory hypercholesterolemia. In consideration of the high prevalence of lipoprotein Lp(a) excess in patients with premature coronary heart disease and the intricate role of lipoprotein Lp(a) in atherothrombosis, this review provides an evidence-based approach to the screening and treatment of patients with lipoprotein Lp(a) excess.
MAIN MESH SUBJECTS: Coronary Disease/BLOOD/*EPIDEMIOLOGY/PREVENTION & CONTROL
Lipoprotein(a)/*BLOOD
ADDITIONAL MESH SUBJECTS: Anticholesteremic Agents/THERAPEUTIC USE
Coronary Arteriosclerosis/BLOOD/EPIDEMIOLOGY/PREVENTION & CONTROL
Diet, Fat-Restricted
Estrogen Replacement Therapy
Female
Human
Hypercholesterolemia/EPIDEMIOLOGY
Life Style
Lipoproteins, LDL Cholesterol/BLOOD
Male
Mass Screening
Middle Age
Risk Factors
PUBLICATION TYPES: JOURNAL ARTICLE
REVIEW
REVIEW, TUTORIAL
LANGUAGE: Eng
REGISTRY NUMBERS: 0 (Anticholesteremic Agents)
0 (Lipoprotein(a))
0 (Lipoproteins, LDL Cholesterol)